Usf vs. Old Dominion Prediction, Odds: 2025 Cure Bowl Matchup Picks by Proven Model

Key Highlights

  • The 2025 Cure Bowl matchup between South Florida Bulls and Old Dominion Monarchs is set for Wednesday.
  • Old Dominion finished second in the Sun Belt East Division with a record of 6-2, while USF went 9-3 overall.
  • USF quarterback Byrum Brown and Old Dominion quarterback Colton Joseph have opted out of the game.
  • The Bulls are favored as -4 point favorites over the Monarchs at DraftKings Sportsbook.
  • The model predicts the Over on the total points scored, with an expected 52.5 points.

2025 Cure Bowl: South Florida vs Old Dominion Preview

The 2025 Cure Bowl matchup between the South Florida Bulls and the Old Dominion Monarchs is set to take place on Wednesday, with kickoff scheduled for 5 p.m. ET at Camping World Stadium in Orlando, Florida.

Team Performance

Old Dominion concluded their regular season with five consecutive victories, finishing second in the Sun Belt East Division with a record of 6-2. The Monarchs outscored their opponents by an impressive margin of 161 points during the season. Meanwhile, South Florida went 9-3 overall and won its last two games as well as three out of four.

Old Dominion’s defensive prowess is evident from their ability to limit opposing teams’ scoring.

They allowed just a small fraction of the points that they scored themselves this year. Conversely, South Florida managed to score more than their opponents by 236 points in 2025. This discrepancy indicates potential for high-scoring action.

Key Players and Coaching Changes

A notable absence is USF quarterback Byrum Brown, who has opted out of the game. Additionally, South Florida head coach Alex Golesh will not be coaching due to taking up a new position at Auburn. This leaves most of his offensive staff also on the sidelines.

Old Dominion’s quarterback, Colton Joseph, remains in the lineup but faces a formidable task against the Bulls’ defense. The Monarchs’ running back Trequan Jones is expected to carry the ball heavily and potentially score multiple touchdowns if he rushes for more than 80 yards.

Prediction from SportsLine Model

The SportsLine Projection Model has analyzed both teams extensively, predicting that the Over on the total points scored will clear at 52.5. According to their projections, South Florida running backs Nykahi Davenport, Sam Franklin, and Alvon Isaac are likely to combine for over 100 yards in rushing.

The model also suggests that Old Dominion’s Trequan Jones could rush for more than 80 yards and even score a touchdown. These predictions indicate an exciting matchup with potential for high-scoring action on the field.

Final Thoughts

The 2025 Cure Bowl promises to be an intriguing contest between two teams with different strengths but facing significant changes in their coaching staffs. While Old Dominion looks to showcase their defensive prowess, South Florida aims to capitalize on their recent form and home-field advantage.

With the model predicting a high-scoring game, fans can expect an action-packed matchup that could go over the 52.5-point total. Whether it’s through the air or on the ground, both teams are set for a thrilling battle in Orlando.

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